Spermidine trihydrochloride: the overall wellbeing booster for cellular health

Discover the benefits of Spermidine trihydrochloride, a powerful nutraceutical for cellular health and longevity. Let’s explore its properties and formulation tips.

The role of spermidine in the body

Spermidine is a naturally occurring polyamine that plays a vital role in cellular metabolism. It is found naturally in various foods and is involved in various biological processes such as DNA stabilization, protein synthesis and cell growth. One of its most notable functions is the induction of autophagy, a process that cleans out damaged cells and regenerates new ones and the main reason behind the interest this molecule is raising within the nutraceutical industry. According to research published in Nature Reviews Molecular Cell Biology, autophagy is a crucial cellular process for maintaining homeostasis and extending lifespan by removing damaged proteins and organelles (Levine & Kroemer, 2008).

Studies have shown that spermidine levels decline with age, correlating with a decrease in autophagy and an increase in age-related diseases. Supplementation with Spermidine trihydrochloride can help counteract these effects by enhancing autophagic activity, thereby promoting cellular rejuvenation and longevity. A study published in Cell Reports found that dietary spermidine extends lifespan and improves cardiac function in mice, suggesting its potential for similar benefits in humans as well (Eisenberg et al., 2016).

Cellular longevity and anti-aging

Spermidine Trihydrochloride ‘s most significant benefit is its ability to induce autophagy, which is crucial for cellular maintenance and longevity. By enhancing autophagy, spermidine helps remove cellular debris, thereby improving cell function and delaying the onset of age-related diseases.

Cardiovascular health

Research indicates that spermidine supplementation can improve cardiovascular health. A study in Circulation Research demonstrated that spermidine intake is associated with reduced blood pressure and improved cardiac function, contributing to better overall heart health (Schroeder et al., 2017).


Spermidine also exhibits neuroprotective properties, primarily due to its role in promoting autophagy and reducing oxidative stress in neurons. It has been shown to improve cognitive function and protect against neurodegenerative diseases (Madeo et al., 2018).

Formulative tips and suggested dosage

Spermidine represents a valuable and versatile opportunity to meet the growing demand for effective anti-aging and health-promoting nutraceutical products. Spermidine trihydrochloride is synthesized through a chemical process that ensures high purity and stability, making it suitable for use in dietary supplements. The compound is characterized by its white crystalline powder form, which is highly soluble in water, allowing for easy incorporation into various supplement formulations.

The optimal dosage of Spermidine trihydrochloride for health benefits is still under investigation; however, studies suggest that a daily dose ranging from 1 to 3 mg is effective for promoting autophagy and improving cellular health (Madeo et al., 2018). To maximize its autophagic effects, Spermidine trihydrochloride is often associated with other antioxidants and anti-aging compounds like resveratrol, quercetin and NMN, while its nootropic activity can be well-paired and complemented by the erinacines and hericenons of Hericium erinaceus extracts.


  • Eisenberg, T., et al. (2016). “Dietary spermidine improves cardiac function and extends lifespan.” Cell Reports.
  • Levine, B., & Kroemer, G. (2008). “Autophagy in the pathogenesis of disease.” Nature Reviews Molecular Cell Biology.
  • Madeo, F., et al. (2018). “Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans.” Nature Reviews Drug Discovery.
  • Schroeder, S., et al. (2017). “Spermidine in health and disease.” Circulation Research.